Galyan Bio Inc., a start-up company in California (USA), is developing first-in-class orally available small molecules for neurodegenerative diseases. Working in close collaboration with Bicoll GmbH since 2019, Galyan Bio discloses now to have a drug candidate, which is intended to slow down the disease in symptomatic patients and delay the manifestation of Huntington disease in symptom-free gene carriers. The start of clinical trials is scheduled for 2022.

“This collaboration once again highlights the wide spectrum of areas where small molecules demonstrate their proven track record. Decades of experience of Bicoll’s synthetic and analytic team have enabled the fast pace optimization program that led to a drug candidate for Galyan Bio. Bicoll is proud of its support to Galyan Bio in all stages of preclinical testing and development, including scaling up of the initial active compounds to multigram scale. Our team is delighted to have contributed to this set of new, patented compounds, which is representing a promising new class of powerful Huntington’s disease drug candidates. We are looking forward to the outcome of the planned clinical trials” said Bicoll GmbH Managing Director Dr. Kai Lamottke.

Dr. Marius Galyan stated: “Bicoll’s continuous support towards integrated small molecule synthesis service combined with ADMET determination enhanced the speed of compound screening rounds considerably. Furthermore, Bicoll’s support in addressing solubility and stability issues of our screening compounds brought us to this success.”