In order to make forward-looking decisions, scientific facts and data which are comprehensible in their generation and interpretation are needed. Quality in terms of safety and efficacy is the central requirement for life science products, whose foundations are already set in the research and development of innovative products. The scientific disciplines of pharmacology and toxicology applied for this purpose are indispensable, the earlier in the development process the better and more sustainable. “Dosis facit venenum (Paracelsus)” is a decisive indication of the complexity of pharmacological and toxicological evaluations of active ingredients, as well as of impurities or degradation products. What are these substances that dissolve out of a product during use? These evaluations, based on understanding and experience are our tasks and far too important to be left to any process. It takes heads, and that is us!