{"id":21572,"date":"2022-12-22T17:05:06","date_gmt":"2022-12-22T16:05:06","guid":{"rendered":"https:\/\/www.izb-online.de\/?p=21572"},"modified":"2023-03-08T11:23:47","modified_gmt":"2023-03-08T10:23:47","slug":"new-high-tech-approach-to-detect-diseased-cells-at-an-early-stage-innovations-und-gruenderzentrum-biotechnologie-izb","status":"publish","type":"post","link":"https:\/\/www.izb-online.de\/en\/izb-biotech-news\/new-high-tech-approach-to-detect-diseased-cells-at-an-early-stage-innovations-und-gruenderzentrum-biotechnologie-izb\/","title":{"rendered":"New high-tech approach to detect diseased cells at an early stage"},"content":{"rendered":"

[vc_row el_class=”gco-magazine-container”][vc_column el_class=”bildspalte”][vc_row_inner][vc_column_inner offset=”vc_col-lg-12 vc_col-md-12″][vc_column_text el_class=”gco-magazine–title”]<\/p>\n

New high-tech approach to detect diseased cells at an early stage<\/h1>\n

[\/vc_column_text][vc_column_text el_class=”gco-magazine-lead”]The robotics-aided spatial-omics technology DISCO-MS developed by research teams at Helmholtz Munich and Max Planck Institute of Biochemistry may help identify new potential therapeutic targets[\/vc_column_text][vc_column_text el_class=”gco-magazine–post-date”]December 2022[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner][vc_column_inner][vc_single_image image=”21561″ img_size=”full”][vc_column_text el_class=”gco-magazine-copyright”]\u00a9 Helmholtz Munich[\/vc_column_text][vc_column_text el_class=”gco-magazine-picture-discription”]Image shows the robotic-aided extraction (DISCO-bot) of atherosclerotic plaque (in gold) from aortic region of a human heart analysed by DISCO-MS technology.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner el_class=”gco-magazine–quote” css=”.vc_custom_1611310713611{margin-top: 33px !important;}”][vc_column_inner][vc_column_text]<\/p>\n

\u201cI am very excited that DISCO-MS offers many early diagnostic and therapeutic opportunities for diseases like dementia and cancer.\u201d<\/h6>\n

Prof. Dr. Ali Ert\u00fcrk, Director Helmholtz Munich<\/p>\n

[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner el_class=”gco-magazine-container–copy” css=”.vc_custom_1591795890737{margin-top: 21px !important;}”][vc_column_inner][vc_column_text]DISCO-MS combines the latest advances in whole specimen imaging with advanced robotics and mass spectrometry technologies to characterize the proteome associated with regions that undergo pathological changes in disease.<\/strong><\/p>\n

How can you trace a single diseased cell in an intact brain or a human heart? The search resembles looking for a needle in a haystack. The teams of Prof. Dr. Ali Ert\u00fcrk at Helmholtz Munich and Prof. Dr. Matthias Mann at the Max Planck Institute of Biochemistry in Martinsried near Munich have now developed a new technology named DISCO-MS that solves the problem. DISCO-MS uses robotics technology to obtain proteomics data from \u2018sick\u2019 cells precisely identified early in the disease.<\/p>\n

Most diseases are asymptomatic initially and the affected persons usually still feel fine – symptoms are not yet present, or still too mild to realize. However, a change has already happened within the body: a virus may have started replicating, or a rogue cell might have divided more often than it should have. But how can these changes be perceived?<\/p>\n

Researchers face a similar dilemma when they are studying the early development of diseases. Even when working with animal models, scientists can rarely pinpoint the small sites of disease initiation or characterize the exact molecular changes that drive disease progression.<\/p>\n

With the development of DISCO-MS by the research teams of Ert\u00fcrk and Mann in Germany, this task has become much easier. DISCO-MS combines methods to turn mouse and human tissues transparent with the latest robotics and proteomics technologies to determine their molecular makeup.[\/vc_column_text][vc_column_text css=”.vc_custom_1583761043671{background-color: #1e73be !important;}” el_class=”redaktionell”][\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner el_class=”three-columns”][vc_column_inner el_class=”bild-drei-spalten-links”][vc_single_image image=”21557″ img_size=”full”][vc_column_text el_class=”gco-magazine-copyright”]\u00a9 Ali Ert\u00fcrk[\/vc_column_text][vc_column_text el_class=”gco-magazine-picture-discription”]Prof. Dr. Ali Ert\u00fcrk<\/strong>, Director Helmholtz Munich[\/vc_column_text][vc_single_image image=”21553″ img_size=”full”][vc_column_text el_class=”gco-magazine-copyright”]\u00a9 Harsharan Singh Bhatia[\/vc_column_text][vc_column_text el_class=”gco-magazine-picture-discription”]Dr. Harsharan Singh Bhatia<\/strong>, Spatial-Omics Team Leader, Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich[\/vc_column_text][vc_single_image image=”21559″ img_size=”full”][vc_column_text el_class=”gco-magazine-copyright”]\u00a9 Friedrun Reinhold[\/vc_column_text][vc_column_text el_class=”gco-magazine-picture-discription”]Prof. Matthias Mann,<\/strong> Head of the Department of Proteomics and Signal Transduction at the Max Planck Institute of Biochemistry[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner el_class=”gco-magazine-container–copy” css=”.vc_custom_1591795890737{margin-top: 21px !important;}”][vc_column_inner][vc_column_text]DISCO-MS: Transparency to detect early molecular changes
\n<\/strong>DISCO-MS starts with the so-called DISCO tissue clearing, which renders the mouse body or human organs transparent – making them accessible to imaging. Thereby, fluorescently labeled cells can be readily identified in intact tissues of specific sites using high-resolution three-dimensional microscopy.<\/p>\n

Once the regions of interest have been identified, they are isolated using a new robotics technology called DISCO-bot, developed by mechanical engineer Furkan \u00d6zt\u00fcrk, a Ph.D. student in Ert\u00fcrk\u2019s lab. The robot-assisted extracted tissues are processed for their proteome analysis using advanced mass spectrometry (MS) methods developed by Andreas-David Brunner, a former Ph.D. student in Mann\u2019s lab. This high-tech approach allows complete molecular characterization of any desired tissue region identified in 3D in whole mouse bodies or human organs.[\/vc_column_text][vc_column_text css=”.vc_custom_1583761043671{background-color: #1e73be !important;}” el_class=”redaktionell”][\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner][vc_column_inner][vc_single_image image=”21555″ img_size=”full”][vc_column_text el_class=”gco-magazine-copyright”]\u00a9 Helmholtz Munich[\/vc_column_text][vc_column_text el_class=”gco-magazine-picture-discription”]Identifying small sites of disease initiation or characterizing the exact molecular changes that drive disease progression is difficult when working with animal models or post-mortem human organs. Bhatia et al. developed DISCO-MS, a 3D spatial-omics technology that uses robotics to obtain proteomics data from cells identified early in diseases. Image shows the aortic regions of a human heart whose vascular plaques are analyzed by DISCO-MS technology.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner el_class=”gco-magazine-container–copy” css=”.vc_custom_1591795890737{margin-top: 21px !important;}”][vc_column_inner][vc_column_text]Early detection catches the diseases<\/strong>
\nTo showcase the method\u2019s power, first author Harsharan Singh Bhatia and colleagues applied DISCO-MS to Alzheimer\u2019s disease (AD) mouse model and to atherosclerotic plaques (pathological hardening and narrowing of blood vessels) in the human heart. In the tissue samples of the AD model, the team applied artificial intelligence (AI) to identify the typical AD plaques at the early stages of the disease, which had been difficult to detect by any other method. Subsequent proteomics analyses of the plaques provided an unbiased and large scale study of proteins affected in AD, revealing new molecular players that could be biomarkers for Alzheimer\u2019s disease.<\/p>\n

In the human heart, the researchers were interested in the composition of the tissues around atherosclerotic plaques, which were quickly visible after tissue clearing. AI detection and robotics extraction of the tissues again allowed the identification of dysregulated molecular pathways in human heart cells related to aortic plaques. These results are key findings, as they form the basis for potential therapeutic targets.<\/p>\n

DISCO-MS is the first spatial-omics technology in intact 3D volumes and accelerates studying complicated diseases ranging from cancer to metabolic disorders. As DISCO-MS works with pre-clinical and clinical tissues, it enables the study of diseases at their earliest stages and, subsequently, the development of potential new therapeutics.<\/p>\n

 <\/p>\n

Original publication:
\n<\/strong>Bhatia et al. (2022). Spatial proteomics in three-dimensional intact specimens. Cell.\u00a0https:\/\/doi.org\/10.1016\/j.cell.2022.11.021<\/a>(Cover)<\/p>\n

 <\/p>\n

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