{"id":16218,"date":"2021-03-12T14:07:18","date_gmt":"2021-03-12T13:07:18","guid":{"rendered":"https:\/\/www.izb-online.de\/t-cells-depressed\/"},"modified":"2021-03-15T12:36:13","modified_gmt":"2021-03-15T11:36:13","slug":"t-cells-depressed","status":"publish","type":"post","link":"https:\/\/www.izb-online.de\/en\/t-cells-depressed\/","title":{"rendered":"T Cells Depressed \u2013 A number of transcription factors and signaling pathways regulate the different states of exhaustion"},"content":{"rendered":"

[vc_row el_class=”gco-magazine-container”][vc_column el_class=”bildspalte”][vc_row_inner][vc_column_inner offset=”vc_col-lg-12 vc_col-md-12″][vc_column_text el_class=”gco-magazine–title”]<\/p>\n

T Cells Depressed \u2013 A number of transcription factors and signaling pathways regulate the different states of exhaustion<\/h1>\n

[\/vc_column_text][vc_column_text el_class=”gco-magazine-lead”]In chronic infections, the immune system can become exhausted. LMU researchers have looked into how this works.[\/vc_column_text][vc_column_text el_class=”gco-magazine–post-date”]March 2021[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner el_class=”two-columns” css=”.vc_custom_1601013418532{margin-top: 25px !important;}”][vc_column_inner el_class=”bild-zwei-spalten-links”][vc_single_image image=”16205″ img_size=”full”][vc_column_text el_class=”gco-magazine-copyright”]\u00a9 Obst Group[\/vc_column_text][vc_column_text el_class=”gco-magazine-picture-discription”] Dr. Reinhard Obst, head of a research group at the Institute for Immunology at LMU’s Biomedical Center at the Campus Martinsried.[\/vc_column_text][vc_single_image image=”16215″ img_size=”full”][vc_column_text el_class=”gco-magazine-copyright”]\u00a9 Obst Group[\/vc_column_text][vc_column_text el_class=”gco-magazine-picture-discription”]Influence of the gene expression of T helper cells through chronic antigen persistence[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner el_class=”gco-magazine–quote” css=”.vc_custom_1601011226550{margin-top: 25px !important;margin-bottom: 25px !important;}”][vc_column_inner][vc_column_text]<\/p>\n

\u201cWe hope now to identify molecules that inhibit transcription factors or signaling pathways which contribute to T cell exhaustion. This could provide a possible strategy to support T cells’ fight against chronic infections and cancer and boost our natural defences against such diseases.\u201d<\/h6>\n

Dr. Reinhard Obst
\nhead of a research group at the Institute for Immunology at LMU’s Biomedical Center at the Campus Martinsried<\/p>\n

[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner el_class=”gco-magazine-container–copy”][vc_column_inner][vc_column_text]T lymphocytes, or T cells, are an important component of our immune system. They can recognize foreign proteins, so-called antigens, as peptide fragments \u2013 for instance, those derived from viruses or cancer cells. In principle, they could, but usually do not, attack our own (‘self’) proteins. “That is why it is important for the organism to tightly control the activities of T cells,” says\u00a0Dr.\u00a0Reinhard\u00a0Obst<\/a>, head of a research group at the Institute for Immunology at LMU’s Biomedical Center that studies the activation of T cells. The project contributed to the\u00a0Collaborative Research\u00a0Center\u00a01054<\/a>\u00a0that explores the plasticity of cell fate decisions in the immune system.<\/p>\n

When viruses gain access to our tissues, T cells are activated to eliminate the pathogens. However, if T cells are exposed to their target antigens for too long, they can lose their functionality and become ‘exhausted.’ They no longer secrete pro-inflammatory messenger molecules, and therefore cannot contribute much to an immune response. On the one hand, it makes sense to keep these cells under control, so as to avoid collateral damage to the organism. On the other, T cell exhaustion makes it difficult to fight chronic diseases, such as those caused by HIV, hepatitis viruses and cancer cells. Understanding immune responses to chronically persisting threats like these is thus one of modern medicine\u2019s great challenges. “This is where T cell exhaustion plays a central role.” the LMU researcher says.<\/p>\n

A new model to study T cell exhaustion
\n<\/strong>Several years ago, Obst developed an animal model which has now yielded important insights. He focused on T helper cells, which express the CD4 marker molecule and make up the largest subset of T cells. Each of these cells recognizes a defined protein fragment as an antigen.<\/p>\n

To control the timing and the amount of the specific antigen expressed in this model system, the LMU scientists used a trick. Their transgenic mice were exposed to different doses of the antibiotic doxycycline, which controls the synthesis of the antigen, via their drinking water. Different amounts of antigen are thus being presented to the T cells in these animals, which avoids the need for experimental infection. “In this way, we are able to regulate the amount of antigen produced,” Obst explains. “Our goal was to find out how the corresponding T helper cells respond.”<\/p>\n

The results showed that the effects were dose dependent: In the presence of high antigen doses, the T cells underwent apoptosis, meaning they died by programmed cell death. At an intermediate dose, however, the T cells survived but quickly lost their functionality. “We demonstrated this state of exhaustion by regulating the amount of antigen that the cells encountered,” the LMU researcher explains. At a low dose, it took several weeks before the cells showed signs of exhaustion. When in further experiments the antigen was subsequently removed, the cells were able to partially recover from their exhausted state. Such dynamic adjustments convinced the researchers that T-helper cells are capable of a surprising degree of plasticity.<\/p>\n

Supporting the T cells\u2019 fight against chronic infections and cancer
\n<\/strong>Obst and his colleagues believe that their findings could have therapeutic implications. The data indicate that a number of transcription factors (proteins that control gene expression) and signaling pathways regulate the different states of exhaustion.<\/p>\n

Two years ago, several groups showed that one of these transcription factors, named Tox, contributes significantly to the exhaustion of T killer cells, another T cell subset. When the Tox gene was deleted, the T-killer cells were less readily exhausted in a chronic infection and could more effectively fight a chronically persisting virus. However, they also attacked the host animals\u2019 organs and died sooner. The new findings suggest that there are several mechanisms in place to adjust T helper cells dynamically to different antigen loads.<\/p>\n

Obst now hopes to identify molecules that inhibit transcription factors or signaling pathways which contribute to T cell exhaustion. This could provide a possible strategy to support T cells’ fight against chronic infections and cancer and boost our natural defences against such diseases.
\n[\/vc_column_text][vc_column_text css=”.vc_custom_1583761043671{background-color: #1e73be !important;}” el_class=”redaktionell”][\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner][vc_column_inner][vc_column_text]<\/p>\n

www.lmu.de<\/a><\/strong><\/p>\n

[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

In chronic infections, the immune system can become exhausted. LMU researchers have looked<\/span> into how this<\/span><\/span><\/p>\n","protected":false},"author":8,"featured_media":16203,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[1540,6402],"tags":[],"class_list":["post-16218","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-campus","category-top-news"],"yoast_head":"\nT Cells Depressed \u2013 A number of transcription factors and signaling pathways regulate the different states of exhaustion - Innovations- und Gr\u00fcnderzentrum Biotechnologie IZB<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.izb-online.de\/en\/t-cells-depressed\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"T Cells Depressed \u2013 A number of transcription factors and signaling pathways regulate the different states of exhaustion\" \/>\n<meta property=\"og:description\" content=\"In chronic infections, the immune system can become exhausted. LMU researchers have looked into how this works.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.izb-online.de\/en\/t-cells-depressed\/\" \/>\n<meta property=\"og:site_name\" content=\"Innovations- und Gr\u00fcnderzentrum Biotechnologie IZB\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-12T13:07:18+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-03-15T11:36:13+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.izb-online.de\/wp-content\/uploads\/2021\/03\/Bild-Beitrag-Dr.-Obst-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"2007\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"martin Reznicek\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"martin Reznicek\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\\\/\\\/www.izb-online.de\\\/en\\\/t-cells-depressed\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.izb-online.de\\\/en\\\/t-cells-depressed\\\/\"},\"author\":{\"name\":\"martin Reznicek\",\"@id\":\"https:\\\/\\\/www.izb-online.de\\\/en\\\/#\\\/schema\\\/person\\\/d8c3fdae36f92a8c67f39af096dd9437\"},\"headline\":\"T Cells Depressed \u2013 A number of transcription factors and signaling pathways regulate the different states of exhaustion\",\"datePublished\":\"2021-03-12T13:07:18+00:00\",\"dateModified\":\"2021-03-15T11:36:13+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.izb-online.de\\\/en\\\/t-cells-depressed\\\/\"},\"wordCount\":1049,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/www.izb-online.de\\\/en\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.izb-online.de\\\/en\\\/t-cells-depressed\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.izb-online.de\\\/wp-content\\\/uploads\\\/2021\\\/03\\\/Bild-Beitrag-Dr.-Obst-scaled.jpg\",\"articleSection\":[\"Campus\",\"Top News\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/www.izb-online.de\\\/en\\\/t-cells-depressed\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.izb-online.de\\\/en\\\/t-cells-depressed\\\/\",\"url\":\"https:\\\/\\\/www.izb-online.de\\\/en\\\/t-cells-depressed\\\/\",\"name\":\"T Cells Depressed \u2013 A number of transcription factors and signaling pathways regulate the different states of exhaustion - Innovations- und Gr\u00fcnderzentrum Biotechnologie IZB\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.izb-online.de\\\/en\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.izb-online.de\\\/en\\\/t-cells-depressed\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.izb-online.de\\\/en\\\/t-cells-depressed\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.izb-online.de\\\/wp-content\\\/uploads\\\/2021\\\/03\\\/Bild-Beitrag-Dr.-Obst-scaled.jpg\",\"datePublished\":\"2021-03-12T13:07:18+00:00\",\"dateModified\":\"2021-03-15T11:36:13+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.izb-online.de\\\/en\\\/t-cells-depressed\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.izb-online.de\\\/en\\\/t-cells-depressed\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.izb-online.de\\\/en\\\/t-cells-depressed\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.izb-online.de\\\/wp-content\\\/uploads\\\/2021\\\/03\\\/Bild-Beitrag-Dr.-Obst-scaled.jpg\",\"contentUrl\":\"https:\\\/\\\/www.izb-online.de\\\/wp-content\\\/uploads\\\/2021\\\/03\\\/Bild-Beitrag-Dr.-Obst-scaled.jpg\",\"width\":2560,\"height\":2007},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.izb-online.de\\\/en\\\/t-cells-depressed\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.izb-online.de\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"IZB Biotech News\",\"item\":\"https:\\\/\\\/www.izb-online.de\\\/en\\\/izb-biotech-news\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Campus\",\"item\":\"https:\\\/\\\/www.izb-online.de\\\/en\\\/izb-biotech-news\\\/campus\\\/\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"T Cells Depressed \u2013 A number of transcription factors and signaling pathways regulate the different states of exhaustion\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.izb-online.de\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/www.izb-online.de\\\/en\\\/\",\"name\":\"Innovations- und Gr\u00fcnderzentrum Biotechnologie IZB\",\"description\":\"Innovations- und Gr\u00fcnderzentrum Biotechnologie\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.izb-online.de\\\/en\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.izb-online.de\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.izb-online.de\\\/en\\\/#organization\",\"name\":\"F\u00f6rdergesellschaft IZB mbH\",\"url\":\"https:\\\/\\\/www.izb-online.de\\\/en\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.izb-online.de\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.izb-online.de\\\/wp-content\\\/uploads\\\/2020\\\/06\\\/izb-logo.svg\",\"contentUrl\":\"https:\\\/\\\/www.izb-online.de\\\/wp-content\\\/uploads\\\/2020\\\/06\\\/izb-logo.svg\",\"width\":1,\"height\":1,\"caption\":\"F\u00f6rdergesellschaft IZB mbH\"},\"image\":{\"@id\":\"https:\\\/\\\/www.izb-online.de\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.izb-online.de\\\/en\\\/#\\\/schema\\\/person\\\/d8c3fdae36f92a8c67f39af096dd9437\",\"name\":\"martin Reznicek\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"T Cells Depressed \u2013 A number of transcription factors and signaling pathways regulate the different states of exhaustion - Innovations- und Gr\u00fcnderzentrum Biotechnologie IZB","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.izb-online.de\/en\/t-cells-depressed\/","og_locale":"en_US","og_type":"article","og_title":"T Cells Depressed \u2013 A number of transcription factors and signaling pathways regulate the different states of exhaustion","og_description":"In chronic infections, the immune system can become exhausted. LMU researchers have looked into how this works.","og_url":"https:\/\/www.izb-online.de\/en\/t-cells-depressed\/","og_site_name":"Innovations- und Gr\u00fcnderzentrum Biotechnologie IZB","article_published_time":"2021-03-12T13:07:18+00:00","article_modified_time":"2021-03-15T11:36:13+00:00","og_image":[{"width":2560,"height":2007,"url":"https:\/\/www.izb-online.de\/wp-content\/uploads\/2021\/03\/Bild-Beitrag-Dr.-Obst-scaled.jpg","type":"image\/jpeg"}],"author":"martin Reznicek","twitter_card":"summary_large_image","twitter_misc":{"Written by":"martin Reznicek","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"NewsArticle","@id":"https:\/\/www.izb-online.de\/en\/t-cells-depressed\/#article","isPartOf":{"@id":"https:\/\/www.izb-online.de\/en\/t-cells-depressed\/"},"author":{"name":"martin Reznicek","@id":"https:\/\/www.izb-online.de\/en\/#\/schema\/person\/d8c3fdae36f92a8c67f39af096dd9437"},"headline":"T Cells Depressed \u2013 A number of transcription factors and signaling pathways regulate the different states of exhaustion","datePublished":"2021-03-12T13:07:18+00:00","dateModified":"2021-03-15T11:36:13+00:00","mainEntityOfPage":{"@id":"https:\/\/www.izb-online.de\/en\/t-cells-depressed\/"},"wordCount":1049,"commentCount":0,"publisher":{"@id":"https:\/\/www.izb-online.de\/en\/#organization"},"image":{"@id":"https:\/\/www.izb-online.de\/en\/t-cells-depressed\/#primaryimage"},"thumbnailUrl":"https:\/\/www.izb-online.de\/wp-content\/uploads\/2021\/03\/Bild-Beitrag-Dr.-Obst-scaled.jpg","articleSection":["Campus","Top News"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/www.izb-online.de\/en\/t-cells-depressed\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/www.izb-online.de\/en\/t-cells-depressed\/","url":"https:\/\/www.izb-online.de\/en\/t-cells-depressed\/","name":"T Cells Depressed \u2013 A number of transcription factors and signaling pathways regulate the different states of exhaustion - Innovations- und Gr\u00fcnderzentrum Biotechnologie IZB","isPartOf":{"@id":"https:\/\/www.izb-online.de\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.izb-online.de\/en\/t-cells-depressed\/#primaryimage"},"image":{"@id":"https:\/\/www.izb-online.de\/en\/t-cells-depressed\/#primaryimage"},"thumbnailUrl":"https:\/\/www.izb-online.de\/wp-content\/uploads\/2021\/03\/Bild-Beitrag-Dr.-Obst-scaled.jpg","datePublished":"2021-03-12T13:07:18+00:00","dateModified":"2021-03-15T11:36:13+00:00","breadcrumb":{"@id":"https:\/\/www.izb-online.de\/en\/t-cells-depressed\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.izb-online.de\/en\/t-cells-depressed\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.izb-online.de\/en\/t-cells-depressed\/#primaryimage","url":"https:\/\/www.izb-online.de\/wp-content\/uploads\/2021\/03\/Bild-Beitrag-Dr.-Obst-scaled.jpg","contentUrl":"https:\/\/www.izb-online.de\/wp-content\/uploads\/2021\/03\/Bild-Beitrag-Dr.-Obst-scaled.jpg","width":2560,"height":2007},{"@type":"BreadcrumbList","@id":"https:\/\/www.izb-online.de\/en\/t-cells-depressed\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.izb-online.de\/en\/"},{"@type":"ListItem","position":2,"name":"IZB Biotech News","item":"https:\/\/www.izb-online.de\/en\/izb-biotech-news\/"},{"@type":"ListItem","position":3,"name":"Campus","item":"https:\/\/www.izb-online.de\/en\/izb-biotech-news\/campus\/"},{"@type":"ListItem","position":4,"name":"T Cells Depressed \u2013 A number of transcription factors and signaling pathways regulate the different states of exhaustion"}]},{"@type":"WebSite","@id":"https:\/\/www.izb-online.de\/en\/#website","url":"https:\/\/www.izb-online.de\/en\/","name":"Innovations- und Gr\u00fcnderzentrum Biotechnologie IZB","description":"Innovations- und Gr\u00fcnderzentrum Biotechnologie","publisher":{"@id":"https:\/\/www.izb-online.de\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.izb-online.de\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.izb-online.de\/en\/#organization","name":"F\u00f6rdergesellschaft IZB mbH","url":"https:\/\/www.izb-online.de\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.izb-online.de\/en\/#\/schema\/logo\/image\/","url":"https:\/\/www.izb-online.de\/wp-content\/uploads\/2020\/06\/izb-logo.svg","contentUrl":"https:\/\/www.izb-online.de\/wp-content\/uploads\/2020\/06\/izb-logo.svg","width":1,"height":1,"caption":"F\u00f6rdergesellschaft IZB mbH"},"image":{"@id":"https:\/\/www.izb-online.de\/en\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/www.izb-online.de\/en\/#\/schema\/person\/d8c3fdae36f92a8c67f39af096dd9437","name":"martin Reznicek"}]}},"_links":{"self":[{"href":"https:\/\/www.izb-online.de\/en\/wp-json\/wp\/v2\/posts\/16218","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.izb-online.de\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.izb-online.de\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.izb-online.de\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/www.izb-online.de\/en\/wp-json\/wp\/v2\/comments?post=16218"}],"version-history":[{"count":23,"href":"https:\/\/www.izb-online.de\/en\/wp-json\/wp\/v2\/posts\/16218\/revisions"}],"predecessor-version":[{"id":16457,"href":"https:\/\/www.izb-online.de\/en\/wp-json\/wp\/v2\/posts\/16218\/revisions\/16457"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.izb-online.de\/en\/wp-json\/wp\/v2\/media\/16203"}],"wp:attachment":[{"href":"https:\/\/www.izb-online.de\/en\/wp-json\/wp\/v2\/media?parent=16218"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.izb-online.de\/en\/wp-json\/wp\/v2\/categories?post=16218"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.izb-online.de\/en\/wp-json\/wp\/v2\/tags?post=16218"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}